By Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)
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Additional resources for Advances in Immunology, Vol. 40
The signals involved in initial activation of B cells and their impact on subsequent proliferation and differentiation were discussed. Two aspects of this process were delineated in detail. First, it was apparent that the nature of the signals transmitted during initial activation determined the capacity of the activated cells to respond subsequently with ongoing proliferation and differentiation.
JELINEK AND PETER E. , 1984; Zubler, 1984). In order to probe the lymphokine requirements of various B cell populations, responsiveness of human peripheral blood, spleen, and lymph node B cells were examined. When anti-IgM and SA and various lymphokines were employed to stimulate the three populations of highly purified B cells, differences were noted in the response patterns (Jelinek and Lipsky, 1987). DNA synthesis by peripheral blood B cells stimulated with soluble F(ab’)s fragments of goat anti-IgM heavy chain specific antibody (anti-p), or SA, was supported by r-IL-2 and T cell supernatant (Table XIV).
JELINEK AND PETER E. LIPSKY secrete Ig subsequently. When hydroxyurea was present for the first 48 hours, subsequent generation of Ig-secreting cells was largely eliminated. This is consistent with the findings that generation of Igsecreting cells requires antecedent DNA synthesis (Jelinek and Lipsky, 1983), although differentiation signals may be conveyed before the initial GI-S interphase. Other studies have also suggested that the presence of T cell factors during the period of time before entry into the S phase of the first cell cycle facilitates the subsequent generation of Ig-secreting cells.