Advances in Topical Antifungal Therapy by R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

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By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

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L1I 101 rklllllm",or tlrH) 8J IpI Illlu4IfIIllltllnl rIr 11 VII III " I '0',,1111' ft' f)(M,,),! ''' U""I 111111 Ilnrl N(Jlhhrif' (I,-OO()OJ) Fig. 2. Clinical improvement of candidosis after start of treatment assessment of therapeutic results (Fig. 3) 2 weeks after the termination of treatment. The outcome was rated as "very good" in 90% of patients treated with bifonazole, 73% of patients treated with Ircolm nl J very good Bifonazole - 27 9()

55 The indications to be tried were: tinea corporis/tinea cruris, tinea pedis interdigitalis, superficial candidosis and pityriasis versicolor. It was up to the investigators to decide which dosage form was to be tried in which indication. Clinical and mycological examinations/check-ups were to be made: prior to treatment, at the end of treatment and 14 days later. Mycological check-ups consisted of the examination of the wet smear and assessment of cultural findings, including the identification of the causative organism.

Concentrations of bifonazole as low as 20 ng/ml produce an almost 100% inhibition of the activity of this keratinolytic enzyme. Our studies provide evidence for a significant anti-inflammatory or antihistaminergic effect of bifonazole in the histamine wheal test similar to that of the hydrocortisone concentration used. The experimental inflammation model of the histamine wheal test allows the implementation of reproducible, quantitative, comparative studies of substances having a relatively weak anti-inflammatory action.

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